A Lab-made Primordial Soup Yields RNA Bases

Friday October 4th, 2019

Looks like Stanley Miller and Harold Urey were onto something with their experiments back in 1952. Their classic abiogenesis research continues to be refined in a new experiment spearheaded by Thomas Carrell. From Nature:

Carell, an organic chemist, and his collaborators have now demonstrated a chemical pathway that — in principle — could have made A, U, C and G (adenine, uracil, cytosine and guanine, respectively) from basic ingredients such as water and nitrogen under conditions that would have been plausible on the early Earth. The reactions produce so much of these nucleobases that, millennium after millennium, they could have accumulated in thick crusts, Carell says. His team describes the results in Science on 3 October1.

The results add credence to the ‘RNA world’ hypothesis, says Carell, who is at the Ludwig Maximilian University of Munich in Germany. This idea suggests that life arose from self-replicating, RNA-based genes — and that only later did organisms develop the ability to store genetic information in the molecule’s close relative, DNA. The chemistry is also a “strong indication” that the appearance of RNA-based life was not an exceedingly lucky event, but one that is likely to happen on many other planets, he adds.

The results, are essential to the Hot Spring Hypothesis and the origin of complex life on Earth. Pretty awesome!


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